GZD-824
货号：
21508-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21508-1mg |
| 描述 | GZD-824 is an orally available inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants including T315I (IC50s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/AblT315I, respectively).1 It has been shown to suppress the proliferation of Bcr/Abl-positive K562 and Ku812 human chronic myelogenous leukemia cells (IC50s = 0.2 and 0.13 nM, respectively) and induce tumor regression in mouse xenograft tumor models driven by either wild-type or mutant Bcr/Abl.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ren, X.,Pan, X.,Zhang, Z., et al. Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib. J. Med. Chem. 56(3), 879-894 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 532.6 |
| 分子式 | C29H27F3N6O |
| CAS号 | 1257628-77-5 |
| 稳定性 | ≥ 2 years |
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