Gilteritinib
货号：
21503-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21503-1mg |
| 描述 | Gilteritinib is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively).1 In preclinical studies, gilteritinib showed strong antileukemic and antitumor effects.2,3 Gilteritinib is currently in several Phase 3 clinical trials for acute myeloid leukemia. |
| 别名 | ASP2215; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mori, M.,Kaneko, N.,Ueno, Y., et al. ASP2215, a novel FLT3/AXL inhibitor: Preclinical evaluation in acute myeloid leukemia (AML). 2014 ASCO Annual Meeting (2014).
2.Ueno, Y.,Kamiyama, M.,Kaneko, N., et al. Gilteritinib (ASP2215), a novel FLT3/AXL inhibitor: Preclinical evaluation in combination with azacitidine in acute myeloid leukemia. Blood 128(22), 2831 (2016).
3.Lee, L.Y.,Hernandez, D.,Rajkhowa, T., et al. Preclinical studies of gilteritinib, a next-generation FLT3 inhibitor. Blood 129(2), 257-260 (2017).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 552.7 |
| 分子式 | C29H44N8O3 |
| CAS号 | 1254053-43-4 |
| 稳定性 | ≥ 2 years |
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