N-Formyl-Met-Leu-Phe
货号：
21495-25mg 基本售价：
350.0 元 规格：
25 mg
产品信息
概述| 货号 | 21495-25mg |
| 描述 | N-Formyl-Met-Leu-Phe (fMLF) is a synthetic peptide that acts as an agonist at formyl peptide receptors (FPRs; Ki = 0.8 pM), which are mainly localized on polymorphonuclear and mononuclear phagocytes.1 Activation of FPRs by fMLF leads to cellular activation, which is characterized by cellular polarization, chemotaxis, and release of proteolytic enzymes.2 fMLF induces contractions in isolated guinea pig jejunum (EC50 = 11 nM), proximal colon (EC50 = 3.5 nM), and distal colon (EC50 = 2.2 nM).3In vitro, fMLF induces neurotransmitter release from enteric motor neurons. |
| 别名 | Chemotactic Peptide;fMLF;NSC 350593; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Panaro, M.A.,Acquafreddo, A.,Sisto, M., et al. Biological role of the N-formyl peptide receptors. Immunopharmacol. Immunotoxicol. 28(1), 103-127 (2006).
2.Wang, W.,Li, T.,Wang, X., et al. FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages. Cell. Mol. Immunol. 12(5), 615-624 (2015).
3.Colucci, M.,Mastriota, M.,Maione, F., et al. Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids. Peptides 32(2), 266-271 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 437.6 |
| 分子式 | C21H31N3O5S |
| CAS号 | 59880-97-6 |
| 稳定性 | ≥ 2 years |
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