| 货号 | 21448-10mg |
| 描述 | N6-Cyclopentyladenosine is a selective agonist at adenosine 1 receptors (A1Rs) (Kis = 2.3, 790, and 43 nM for A1R, A2R, and A3R receptors, respectively, in transfected CHO cells).1,2 When microinjected into the rat brainstem, it increases blood pressure and heart rate.3 It is effective for pain in normal and nerve-injured rats and shows anticonvulsant activity in a rat model of generalized seizures.4,5 |
| 别名 | CPA;UK 80882; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Klotz, K.-N. Adenosine receptors and their ligands. Naunyn-Schmiedebergs Arch. Pharmacol. 362(4), 382-391 (2000). 2.Klotz, K.-N.,Hessling, J.,Hegler, J., et al. Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedebergs Arch. Pharmacol. 357, 1-9 (1998). 3.Barraco, R.A.,el-Ridi, M.R.,Ergene, E., et al. Adenosine receptor subtypes in the brainstem mediate distinct cardiovascular response patterns. Brain Res. Bull. 26(1), 59-84 (1991). 4.Gong, Q.-J.,Li, Y.-Y.,Xin, W.-J., et al. Differential effects of adenosine A1 receptor on pain-related behavior in normal and nerve-injured rats. Brain Res. 1361, 23-30 (2010). 5.Jaishree, J.,Kumaresan, S.,Sudha, S., et al. Individual and combined effects of N6-cyclopentyladenosine, flunarizine and diazepam on aminophylline-induced recurrent generalized seizures in mice. Pol. J. Pharmacol. 55(4), 559-564 (2003). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥99% |
| 计算分子量 | 335.4 |
| 分子式 | C15H21N5O4 |
| CAS号 | 41552-82-3 |
| 稳定性 | ≥ 1 year |
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