NSC 95397
货号：
21431-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21431-1mg |
| 描述 | NSC 95397 is a 1,4-naphthoquinone-based irreversible inhibitor of Cdc25 dual-specificity phosphatases, with Ki values of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively.1 It displays >125-fold selectivity for Cdc25 over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. NSC 95397 significantly inhibits the growth of human and murine carcinoma cells, blocking G2/M phase transition.1,2 In rat liver epithelial cells, NSC 95397 induces cell cycle arrest, which is associated with phosphorylation of EGFR, activation of ERK1/2, phosphorylation of connexin43, and downregulation of gap junctional intercellular communication.3 |
| 别名 | Cdc25 Inhibitor IV;PTP Inhibitor XXIX; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lazo, J.S.,Nemoto, K.,Pestell, K.E., et al. Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. Mol. Pharmacol. 61(4), 720-728 (2002).
2.Han, Y.,Shen, H.,Carr, B.I., et al. NAD(P)H:quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors. J. Pharmacol. Exp. Ther. 309(1), 64-70 (2004).
3.Melchheier, I.,von Montfort, C.,Stuhlmann, D., et al. Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation. Biochem. Biophys. Res. Commun. 327(4), 1016-1023 (2005).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 310.4 |
| 分子式 | C14H14O4S2 |
| CAS号 | 93718-83-3 |
| 稳定性 | ≥ 2 years |
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