| 货号 | 21398-1mg |
| 描述 | Methyllycaconitine (MLA) is an antagonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs; Ki = 1.4 nM).1,2 It is less effective at other nAChRs.3,4 MLA is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.5,6 |
| 别名 | MLA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kalappa, B.I.,Sun, F.,Johnson, S.R., et al. A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia. Brit.J.Pharmacol. 169, 1862-1878 (2013). 2.Ward, J.M.,Cockcroft, V.B.,Lunt, G.G., et al. Methyllycaconitine: A selective probe for neuronal α-bungarotoxin binding sites. FEBS Lett. 270(1-2), 45-48 (1990). 3.Eaton, J.B.,Peng, J.H.,Schroeder, K.M., et al. Characterization of human α4β 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells. Molecular Pharmacology 64(6), 1283-1294 (2003). 4.Grinevich, V.P.,Letchworth, S.R.,Lindenberger, K.A., et al. Heterologous expression of human α6β4β3α5 nicotinic acetylcholine receptors: Binding properties consistent with their natural expression require quaternary subunit assembly including the α5 subunit. J. Pharm. Exp. Ther. 312(2), 619-626 (2005). 5.Fan, B.-S.,Zhang, E.-H.,Wu, M., et al. Activation of α7 nicotinic acetylcholine receptor decreases on-site mortality in crush syndrome through insulin signaling-Na/K-ATPase pathway. Front. Pharmacol. 7, 79 (2016). 6.Liu, L.,Yu, J.,Zhang, B., et al. Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine. Sci. Rep. 7, 40467 (2017). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 874.9 |
| 分子式 | C37H50N2O10 • C6H8O7 |
| CAS号 | 351344-10-0 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |