| 货号 | 21304-1g |
| 描述 | Hydrochlorothiazide (HCTZ) is a thiazide diuretic that inhibits the apical membrane sodium chloride cotransporter in the distal and collecting duct nephron segments.1,2,3 Diuretics, including HCTZ, have been abused as performance-enhancing drugs and masking agents in sports doping.4,5 |
| 别名 | HCTZ;NSC 53477;SU 5879; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Odlind, B. and Lönnerholm, G. Renal tubular secretion and effects of chlorothiazide, hydrochlorothiazide and clopamide: A study in the avian kidney. Acta.Pharmacol.Toxicol (Copenh) 51(3), 187-197 (1982). 2.Majid, D.S.A. and Navar, L.G. Blockade of distal nephron sodium transport attenuates pressure natriuresis in dogs. Hypertension 23(6 Pt 2), 1040-1045 (1994). 3.Vongpatanasin, W. Hydrochlorothiazide (HCTZ) is not the most useful nor versatile thiazide diuretic. Curr. Opin. Cardiol. 30(4), 361-365 (2015). 4.Cadwallader, A.B.,de la Torre, X.,Tieri, A., et al. The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: Pharmacology, toxicology and analysis. Br. J. Pharmacol. 161(1), 1-16 (2010). 5.Deventer, K.,Pozo, O.J.,Van Eenoo, P., et al. Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis. J. Chromatogr. A 1216(12), 2466-2473 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 297.7 |
| 分子式 | C7H8ClN3O4S2 |
| CAS号 | 58-93-5 |
| 稳定性 | ≥ 2 years |
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