Velpatasvir
货号：
21280-10mg 基本售价：
350.0 元 规格：
10 mg
产品信息
概述| 货号 | 21280-10mg |
| 描述 | Velpatasvir is a second generation direct-acting inhibitor of NS5A, a non-structural protein required for replication of the hepatitis C virus (HCV).1 It has broad antiviral activity in vitro against the HCV strain subtypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, 6a, and 6e (EC50 = 6-130 pM).2 A phase 1 clinical trial concluded that once daily doses of velpatasvir from 5-150 mg were well tolerated and provided significant viral reduction.3 |
| 别名 | GS-5816; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nakamoto, S.,Kanda, T.,Wu, S., et al. Hepatitis C virus NS5A inhibitors and drug resistance mutations. World J. Gastroenterol. 20(11), 2902-2912 (2014).
2.Cheng, G.,Yu, M.,Peng, B., et al. 1191 GS-5816, a second generation HCV NS5A inhibitor with potent antiviral activity broad genotypic coverage and a high resistance barrier. J. Hepatol. 58(S1), S484-S485 (2013).
3.Lawitz, E.,Freilich, B.,Link, B., et al. A phase 1, randomized, dose-ranging study of GS-5816, a once-daily NS5A inhibitor, in patients with genotype 1-4 hepatitis C virus. J. Viral. Hepat. 22(12), 1011-1019 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 883 |
| 分子式 | C49H54N8O8 |
| CAS号 | 1377049-84-7 |
| 稳定性 | ≥ 2 years |
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