CEP-37440
货号：
21278-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21278-1mg |
| 描述 | CEP-37440 is a dual inhibitor of focal adhesion kinase 1 (FAK1; IC50s = 2.0 and 80 nM for in vitro enzyme and cellular inhibition, respectively) and anaplastic lymphoma kinase (ALK; IC50s = 3.1 and 22 nM for in vitro enzyme and cellular inhibition, respectively).1,2 It blocks the proliferation of inflammatory and triple-negative breast cancer cell lines but not normal breast epithelial cells.2 CEP-37440 reduces the growth and metastasis of breast cancer xenografts in mice when given by oral gavage.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ott, G.R.,Cheng, M.,Learn, K.S., et al. Discovery of clinical candidate CEP-37440, a selective inhibitor of focal adhesion kinase (FAK) and anaplastic lymphoma kinase (ALK). J. Med. Chem. 59(16), 7478-7496 (2016).
2.Salem, I.,Alsalahi, M.,Chervoneva, I., et al. The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells. Breast Cancer Res. 18(1), 37 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 580.1 |
| 分子式 | C30H38ClN7O3 |
| CAS号 | 1391712-60-9 |
| 稳定性 | ≥ 2 years |
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