SB-674042
货号：
21270-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21270-1mg |
| 描述 | SB-674042 is a potent and selective non-peptide orexin 1 receptor (OX1R) antagonist (Kd = 5.03 and 3.76 nM in whole cell binding and membrane-based assays, respectively).1 In calcium mobilization studies, it was >100-fold selective for OX1 over OX2 and did not show significant affinity for serotonergic, dopaminergic, adrenergic, or purinergic receptors at concentrations up to 10 µM.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Langmead, C.J.,Jerman, J.C.,Brough, S.J., et al. Characterisation of the binding of 3H-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br. J. Pharmacol. 141(2), 340-346 (2004).
2.Ellis, J.,Pediani, J.D.,Canals, M., et al. Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function. J. Biol. Chem. 281(50), 38812-38824 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 448.5 |
| 分子式 | C24H21FN4O2S |
| CAS号 | 483313-22-0 |
| 稳定性 | ≥ 2 years |
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