| 货号 | 21245-1g |
| 描述 | (±)-Epinephrine is a natural neurotransmitter that is released from the adrenal medulla and activates adrenoceptors (Kis = 15, 735, and 3,970 nM for α1A-, β2-, and β1-adrenergic receptors, respectively).1,2,3 Through these receptors, (±)-epinephrine may induce either contraction or relaxation of vascular smooth muscle, depending on adrenoceptor subtype expression.3 Receptor-mediated actions of (±)-epinephrine are also relevant to blocking anaphylaxis, reversing cardiac arrest, and reducing bleeding in clinical trials.4,5,6 |
| 别名 | (±)-Adrenaline;DL-Adrenaline;DL-Epinephrine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rothman, R.B.,Vu, N.,Partilla, J.S., et al. In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates. J. Pharmacol. Exp. Ther. 307(1), 138-145 (2003). 2.Hoffmann, C.,Leitz, M.R.,Oberdorf-Maass, S., et al. Comparative pharmacology of human β-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedebergs Arch. Pharmacol. 369(2), 151-159 (2004). 3.Ahles, A. and Englehardt, S. Polymorphic variants of adrenoceptors: Pharmacology, physiology, and role in disease. Pharmacol. Rev. 66(3), 598-637 (2014). 4.Werner-Busse, A.,Zuberbier, T. and Worm, M. The allergic emergency--management of severe allergic reactions. J.Dtsch.Dermatol.Ges. 12(5), 379-387 (2014). 5.Chen, S.q. Advances in clinical studies of cardiopulmonary resuscitation. World J.Emerg.Med. 6(2), 85-93 (2015). 6.Wilkins, T.,Khan, N.,Nabh, A., et al. Diagnosis and management of upper gastrointestinal bleeding. American Family Physician 85(5), 469-476 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 219.7 |
| 分子式 | C9H13NO3 • HCl |
| CAS号 | 329-63-5 |
| 稳定性 | ≥ 2 years |
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