Gly-Pro-pNA (hydrochloride)
货号：
21244-10mg 基本售价：
350.0 元 规格：
10 mg
产品信息
概述| 货号 | 21244-10mg |
| 描述 | Gly-Pro-pNA is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV).1 Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm. DPP IV inactivates the two peptides responsible for a majority of nutrient-stimulated insulin secretion: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1). This substrate can be used to screen for DPP IV inhibitors, which have emerged as a new class of experimental antidiabetic agents.2 |
| 别名 | Gly-Prop-nitroanilide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kim, Y.B.,Kopcho, L.M.,Kirby, M.S., et al. Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118). Arch. Biochem. Biophys. 445(1), 9-18 (2006).
2.Kushwaha, R.N.,Haq, W. and Katti, S.B. Discovery of 17 gliptins in 17-years of research for the treatment of type 2 diabetes: A synthetic overview. Chemistry and Biology Interface 4(3), 137-162 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 328.8 |
| 分子式 | C13H16N4O4 • HCl |
| CAS号 | 103213-34-9 |
| 稳定性 | ≥ 2 years |
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