| 货号 | 21235-1mg |
| 描述 | (+)-PD 128907 is a potent agonist of the dopamine 3 (D3) receptor (Ki = 1 nM).1,2 It shows selectivity for D3 over D2 and D4 receptors (Kis = 1.2 and 7 µM, respectively).1 Low doses of (+)-PD 128907 (13 µg/kg, s.c.) reduce spontaneous locomotor activity in rats.3 It blocks stereotypy induced by the NMDA receptor antagonist (+)-MK-801 (Item No. 10009019) in mice.4 (+)-PD 128907 is used in animal models to study the role of the D3 receptor in nervous system disorders, such as schizophrenia, Parkinson’s disease, and depression.5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Akunne, H.C.,Towers, P.,Ellis, G.J., et al. Characterization of binding of [3H]PD 128907, a selective dopamine D3 receptor agonist ligand, to CHO-K1 cells. Life Sci. 57(15), 1401-1410 (1995). 2.Pugsley, T.A.,Davis, M.D.,Akunne, H.C., et al. Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. J. Pharmacol. Exp. Ther. 275(3), 1355-1366 (1995). 3.Bristow, L.J.,Cook, G.P.,Gay, J.C., et al. The behavioural and neurochemical profile of the putative dopamine D3 receptor agonist, (+)-PD 128907, in the rat. Neuropharmacology 35(3), 285-294 (1996). 4.Witkin, J.,Gasior, M.,Acri, J., et al. Atypical antipsychotic-like effects of the dopamine D3 receptor agonist, (+)-PD 128,907. Eur. J. Pharmacol. 347(2-3), R1-R3 (1998). 5.Carcinella, S.,Drui, G.,Boulet, S., et al. Implication of dopamine D3 receptor activation in the reversion of Parkinson’s disease-related motivational deficits. Transl.Psychiatry 4(e401), (2014). 6.Gil-Mast, S.,Kortagere, S.,Kota, K., et al. An amino acid residue in the second extracellular loop determines the agonist-dependent tolerance property of the human D3 dopamine receptor. ACS Chem Neurosci. 4(6), 940-951 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 285.8 |
| 分子式 | C14H19NO3 • HCl |
| CAS号 | 300576-59-4 |
| 稳定性 | ≥ 2 years |
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