Dorsomorphin (hydrochloride)
货号：
21207-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21207-1mg |
| 描述 | Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK; Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3.1 Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6).2 Independent of AMPK inhibition, dorsomorphin, at 10 μM, has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.3 |
| 别名 | BML-275;Compound C;CpdC; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhou, G.,Myers, R.,Li, Y., et al. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108(8), 1167-1174 (2001).
2.Yu, P.B.,Hong, C.C.,Sachidanandan, C., et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature Chemical Biology 4(1), 33-41 (2008).
3.Vucicevic, L.,Misirkic, M.,Janjetovic, K., et al. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy 7(1), 40-50 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 472.4 |
| 分子式 | C24H25N5O • 2HCl |
| CAS号 | 1219168-18-9 |
| 稳定性 | ≥ 2 years |
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