Necrostatin-1 Inactive Control
货号：
21192-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21192-1mg |
| 描述 | Necrostatin-1 Inactive Control (Nec-1i) is a demethylated variant of necrostatin-1 (Nec-1; Item No. 11658), a RIP1 kinase inhibitor.1 While both Nec-1 and Nec-1i inhibit the immune regulator indoleamine 2,3-dioxygenase, Nec1i is ~ 100-fold less effective than Nec-1 in inhibiting RIP1 kinase in vitro and 10-fold less potent than Nec-1 in a mouse necroptosis assay.2 However, equally high doses of Nec-1 and Nec-1i are reported to inhibit TNF-induced systemic inflammatory response syndrome in vivo.2 Nec-1i is often used as an inactive control in studies using Nec-1 to exclude nonspecific off-target effects. |
| 别名 | Nec-1i; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Degterev, A.,Hitomi, J.,Germscheid, M., et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chemical Biology 4(5), 313-321 (2008).
2.Takahashi, N.,Duprez, L.,Grootjans, S., et al. Necrostatin-1 analogues: Critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis. 3, e437 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 245.3 |
| 分子式 | C12H11N3OS |
| CAS号 | 64419-92-7 |
| 稳定性 | ≥ 2 years |
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