DR2313
货号：
21181-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21181-1mg |
| 描述 | DR2313 is an inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 0.2 and 0.24 µM for PARP1 and PARP2, respectively, in nuclear rat brain extracts).1 It is selective for PARP, with no effect on GAPDH, ADH, LDH, or on lipid peroxidation. DR2313 is competitive with NAD+ at the catalytic site of PARP with a Ki value of 0.23 µM. Pretreatment of primary rat cortical cultures prevents cell death (EC50 = 0.27 µM), and, in vivo, it reduces infarct volume in a rat model of cerebral ischemia. DR2313 has been used to investigate cell death after middle cerebral artery occlusion.2 |
| 别名 | PARP Inhibitor XI; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nakajima, H.,Kakuki, N.,Ohkuma, K., et al. A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: Pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J. Pharmacol. Exp. Ther. 312(2), 472-481 (2005).
2.Xu, Z.,Zhang, J.,David, K.K., et al. Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299(1), R215-R221 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 182.2 |
| 分子式 | C8H10N2OS |
| CAS号 | 284028-90-6 |
| 稳定性 | ≥ 2 years |
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