| 货号 | 21175-250mg |
| 描述 | Zymosan A is a glucan derived from the cell wall of S. cerevisiae that activates toll-like receptor 2 (TLR2) and a C-type lectin, dectin-1, on macrophages, monocytes, and dendritic cells to induce inflammatory signaling.1,2,3,4 It is commonly used to stimulate a sterile inflammatory response in mouse models of sepsis, shock, and peritonitis.5,6 In a mouse model of sepsis/shock, a lethal dose of zymosan A (500 mg/kg) in rats induced inflammation and shock leading to death.5 Zymosan A can also induce biosynthesis of eicosanoids.7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Di Carlo, F.J. and Fiore, J.V. On the composition of zymosan. Science 127(3301), 756-757 (1958). 2.Brown, G.D. and Gordon, S. Immune recognition: A new receptor for β-glucans. Nature 413(6851), 36-37 (2001). 3.Pillemer, L.,Blum, L.,Lepow, I.H., et al. The properdin system and immunity. III. The zymosan assay of properdin. J. Exp. Med. 103(1), 1-13 (1956). 4.Underhill, D.M.,Ozinsky, A.,Hajjar, A.M., et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401(6755), 811-815 (1999). 5.Reynolds, F.D.,Dauchy, R.,Blask, D.E., et al. The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A. Surgery 134(3), 474-479 (2003). 6.Rao, T.S.,Currie, J.L.,Shaffer, A.F., et al. In Vivo characterization of zymosan-induced mouse peritoneal inflammation. Journal of Pharmacology and Experimental Therapeutics 269(3), 917-925 (1994). 7.Humes, J.L.,Sadowski, S.,Galavage, M., et al. Evidence for two sources of arachidonic acid for oxidative metabolism by mouse peritoneal macrophages. J. Biol. Chem. 257(4), 1591-1594 (1982). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| CAS号 | 58856-93-2 |
| 稳定性 | ≥ 1 year |
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