| 货号 | 21117-1mg |
| 描述 | LXR-623 is a liver X receptor (LXR) modulator that acts as a partial agonist at LXRα and a full agonist at LXRβ (IC50s = 179 and 24 nM, respectively).1,2 It is orally bioavailable and readily passes the blood-brain barrier.1,2,3 LXR-623 is anti-atherogenic in animal models of atherosclerosis, showing synergistic effects when combined with simvastatin (Item Nos. 10010344|10010345).1,4,2 |
| 别名 | WAY-252623; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.DiBlasio-Smith, E.,Arai, M.,Quinet, E.M., et al. Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J. Transl. Med. 6, 59 (2008). 2.Quinet, E.M.,Basso, M.D.,Halpern, A.R., et al. LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J. Lipid. Res. 50(12), 2358-2370 (2009). 3.Villa, G.R.,Hulce, J.J.,Zanca, C., et al. An LXR-cholesterol axis creates a metabolic co-dependency for brain cancers. Cancer Cell. 30(5), 683-693 (2016). 4.Giannarelli, C.,Cimmino, G.,Connolly, T.M., et al. Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: An magnetic resonance imaging study in a model of advanced atherosclerosis. Eur. Heart J. 33(2), 264-273 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 422.8 |
| 分子式 | C21H12ClF5N2 |
| CAS号 | 875787-07-8 |
| 稳定性 | ≥ 2 years |
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