Verubecestat
货号：
21115-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21115-1mg |
| 描述 | Verubecestat is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and BACE2 (Kis = 2.2 and 0.38 nM, respectively).1 It has a high selectivity for BACE1 and BACE2 over closely related aspartyl proteases, including cathepsin D.1 Formulations containing verubecestat profoundly lower levels of β-amyloid proteins in brain and cerebrospinal fluid (CSF) in rats and nonhuman primates and in CSF in humans.1,2 |
| 别名 | MK-8931; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Scott, J.D.,Li, S.W.,Brunskill, A.P.J., et al. Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-dioxide derivative verubecestat (MK-8931)- a β-site amyloid precursor protein cleaving enzyme 1 inhibitor for the treatment of Alzheimer’s disease. J. Med. Chem. 59(23), 10435-10450 (2016).
2.Kennedy, M.E.,Stamford, A.W.,Chen, X., et al. The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients. Sci. Transl. Med. 8(363), 363ra150 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 409.4 |
| 分子式 | C17H17F2N5O3S |
| CAS号 | 1286770-55-5 |
| 稳定性 | ≥ 2 years |
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