GDC-0994
货号：
21107-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 21107-500ug |
| 描述 | GDC-0994 is a potent and selective ERK1 and ERK2 inhibitor with IC50 values of 6.1 and 4.1 nM, respectively.1 It inhibits ERK-dependent p90RSK serine 380 phosphorylation in PMA-stimulated HepG2 cells with an IC50 value of 12 nM. GDC-0994 inhibited growth of HCT116 human colorectal cancer xenograft tumors by 49%, 57%, and 80% at 30, 60, and 100 mg/kg, respectively, when administered orally once daily for 21 days.1 |
| 别名 | RG-7842; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Blake, J.F.,Burkard, M.E.,Chan, J., et al. Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an extracellular signal-regulated kinase ½ (ERK1/2) inhibitor in early clinical development. J. Med. Chem. 59(12), 5650-5660 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 440.9 |
| 分子式 | C21H18ClFN6O2 |
| CAS号 | 1453848-26-4 |
| 稳定性 | ≥ 2 years |
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