Phenserine
货号：
21060-5mg 基本售价：
350.0 元 规格：
5 mg
产品信息
概述| 货号 | 21060-5mg |
| 描述 | Phenserine is an analog of physostigmine (Item No. 13027) that inhibits acetylcholinesterase with an IC50 value of 24 nM.1,2 It is reported to prevent amyloid-β production by diminishing the expression of amyloid-β precursor protein.3 |
| 别名 | (-)-Eseroline phenylcarbamate;(-)-N-Phenylcarbamoyleseroline;(-)-Phenserine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yu, Q.S.,Zhu, X.,Holloway, H.W., et al. Anticholinesterase activity of compounds related to geneserine tautomers. N-oxides and 1,2-oxazines. J. Med. Chem. 45(17), 3684-3691 (2002).
2.Luo, W.,Yu, Q.S.,Kulkarni, S.S., et al. Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (−)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J. Med. Chem. 49(7), 2174-2185 (2006).
3.Utsuki, T.,Yu, Q.-s.,Davidson, D., et al. Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer’s disease amyloid-β peptide. J. Pharmacol. Exp. Ther. 318(2), 855-862 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 337.4 |
| 分子式 | C20H23N3O2 |
| CAS号 | 101246-66-6 |
| 稳定性 | ≥ 2 years |
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