| 货号 | 21059-1mg |
| 描述 | PD 168393 is a cell-permeable, irreversible inhibitor of EGFR kinase activity (IC50 = 0.70 nM).1 It is effective in vivo, suppressing the growth of human epidermoid carcinoma xenografts in mice.1 PD 168393 is used in cells and in vivo to irreversibly inhibit EGFR signaling.2,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fry, D.W.,Kraker, A.J.,McMichael, A., et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265(5175), 1093-1095 (1994). 2.Pulit-Penaloza, J.A.,Sapkota, B.,Esser, E.S., et al. Modulation of influenza vaccine immune responses using an epidermal growth factor receptor kinase inhibitor. Sci. Rep. 5, 12321 (2015). 3.Sun, X.,Liang, J.,Yao, X., et al. The activation of EGFR promotes myocardial tumor necrosis factor-α production and cardiac failure in endotoxemia. Oncotarget 6(34), 35478-35495 (2015). 4.Wang, S.H.,Wang, S.C.,Chen, P.C., et al. Induction of cyclooxygenase-2 gene by Candida albicans through EGFR, ERK, and p38 pathways in human urinary epithelium. Med. Mycol. Epub ahead of print, (2016). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 369.2 |
| 分子式 | C17H13BrN4O |
| CAS号 | 194423-15-9 |
| 稳定性 | ≥ 2 years |
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