CB-1954
货号：
21023-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21023-1mg |
| 描述 | CB-1954 is a prodrug that is enzymatically activated to generate an antitumor agent that forms DNA-DNA interstrand crosslinks.1 In rat Walker 256 carcinoma cells, CB-1954 is reduced by NAD(P)H:quinone oxidoreductase (NQO1) to the cytotoxic derivative 5-(aziridin-1-yl)-4-hydroxylamineo 2 nitrobenzamide, a bifunctional alkylating agent.1 |
| 别名 | NSC 115829;Tretazicar; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Knox, R.J.,Jenkins, T.C.,Hobbs, S.M., et al. Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy. Cancer Res. 60(15), 4179-4186 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 252.2 |
| 分子式 | C9H8N4O5 |
| CAS号 | 21919-05-1 |
| 稳定性 | ≥ 2 years |
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