NS 1738
货号：
21018-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21018-1mg |
| 描述 | NS 1738 is a positive allosteric modulator of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs).1 When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7 nAChRs (EC50 = 3.4 µM).1 NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats.1 NS 1738 also improves performance in the rat social recognition test.1 NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.2,3 |
| 别名 | NSC 213859; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Timmermann, D.B.,Gronlien, J.H.,Kohlhaas, K.L., et al. An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. JPET 323(1), 294-307 (2007).
2.Cheng, Q. and Yakel, J.L. Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation. J. Neurosci. 34(1), 124-133 (2014).
3.Freitas, K.,Carroll, F.I. and Damaj, M.I. The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models. J. Pharmacol. Exp. Ther. 344(1), 264-275 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 365.1 |
| 分子式 | C14H9Cl2F3N2O2 |
| CAS号 | 501684-93-1 |
| 稳定性 | ≥ 2 years |
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