Amiselimod (hydrochloride)
货号：
20970-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20970-1mg |
| 描述 | Amiselimod is a prodrug that is converted to (S)-amiselimod phosphate by sphingosine kinases.1 Amiselimod phosphate is a highly selective S1P1 receptor antagonist (EC50 = 74 pM) that is without activity at S1P3receptors.1 It is approximately five-fold weaker as an activator of G protein-coupled inwardly rectifying K+ (GIRK) channels than fingolimod phosphate.1 Amiselimod is orally bioavailable and has minimal cardiac effects when tested clinically.1 |
| 别名 | MT-1303; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sugahara, K.,Maeda, Y.,Shimano, K., et al. Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk. Br. J. Pharmacol. 174(1), 15-27 (2017).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 413.9 |
| 分子式 | C19H30F3NO3 • HCl |
| CAS号 | 942398-84-7 |
| 稳定性 | ≥ 2 years |
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