HC-067047
货号：
20927-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20927-1mg |
| 描述 | HC-067047 is a TRPV4 antagonist that reversibly inhibits currents through human, rat, and mouse TRPV4 orthologs (IC50s = 48, 133, and 17 nM, respectively).1 It is selective for TRPV4 over TRPV1, TRPV2, TRPV3, and TRPM8 channels.1 HC-067047 has been shown to increase functional bladder capacity and to reduce micturition frequency in wild-type mice and rats with cystitis.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Everaerts, W.,Zhen, X.,Ghosh, D., et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc. Natl. Acad. Sci. USA 107(44), 19084-19089 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 471.5 |
| 分子式 | C26H28F3N3O2 |
| CAS号 | 883031-03-6 |
| 稳定性 | ≥ 2 years |
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