| 货号 | 20919-1mg |
| 描述 | Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABAA receptor current.1,2 At nanomolar concentrations, it can potentiate GABA-evoked currents at GABAA receptor complexes containing α1, α2, α3, β2, and γ2L subunits expressed in Xenopusoocytes.1,2 Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.3,4,5 |
| 别名 | CCD 1042; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Greenfield, L.J., Jr. Molecular mechanisms of antiseizure drug activity at GABAA receptors. Seizure 22(8), 589-600 (2013). 2.Luszczki, J.J. Third-generation antiepileptic drugs: Mechanisms of action, pharmacokinetics and interactions. Pharmacological Reports 6, 197-216 (2009). 3.Aneja, S. and Sharma, S. Newer anti-epileptic drugs. Indian Pediatr. 50(11), 1033-1040 (2013). 4.Reddy, D.S. Neurosteroids: Endogenous role in the human brain and therapeutic potentials. Progress in Brain Research 186, 113-137 (2010). 5.Rogawski, M.A. Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Research 69(3), 273-294 (2006). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 332.5 |
| 分子式 | C22H36O2 |
| CAS号 | 38398-32-2 |
| 稳定性 | ≥ 2 years |
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