MY-5445
货号：
20872-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20872-1mg |
| 描述 | MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a Ki value of 1.3 µM.1,2 It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 µM, respectively.1 MY-5445 has been shown to relax intact strips of rat aorta with an EC50 value of 4 µM.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Souness, J.E.,Brazdil, R.,Diocee, B.K., et al. Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine. Br. J. Pharmacol. 98(3), 725-734 (1989).
2.Yamamoto, T.,Yamamaoto, S.,Osborne, J.C., Jr., et al. Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase. J. Biol. Chem. 258(23), 14173-14177 (1983).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 331.8 |
| 分子式 | C20H14ClN3 |
| CAS号 | 78351-75-4 |
| 稳定性 | ≥ 2 years |
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