| 货号 | 20870-1mg |
| 描述 | CD3254 is a selective agonist of the retinoid X receptors (RXRs; EC50 = ~10 nM for human RXRβ) that is without effect on retinoic acid receptors (RARs).1,2 It stimulates the recruitment of the nuclear receptor interaction domain of the TRAP220 coactivator to RXRα/RARβ heterodimers in vitro.3 CD3254 also enhances the recruitment of the PPARγ coactivator 1α, PGC-1α, to RXRα/PPARγ heterodimers.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Nahoum, V.,Pérez, E.,Germain, P., et al. Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. Proc. Natl. Acad. Sci. USA 104(44), 17323-17328 (2007). 2.Jurutka, P.W.,Kaneko, I.,Yang, J., et al. Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: Novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD3254). J. Med. Chem. 56(21), 8432-8454 (2013). 3.Pogenberg, V.,Guichou, J.-F.,Vivat-Hannah, V., et al. Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies. J. Biol. Chem. 280(2), 1625-1633 (2005). 4.le Maire, A.,Grimaldi, M.,Roecklin, D., et al. Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO reports 10(4), 367-373 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 364.5 |
| 分子式 | C24H28O3 |
| CAS号 | 196961-43-0 |
| 稳定性 | ≥ 2 years |
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