TX-1918
货号：
20840-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20840-1mg |
| 描述 | TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM).1 It inhibits Src, PKA, PKC, and EGFR kinases at much higher concentrations (IC50s = 4.4, 44, 44, and 440 µM, respectively).1 TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells (EC50s = 2.07 and 230 µM, respectively) with ≥5,000-fold and ≥90-fold reduced mitochondrial- and hepato-toxicity, respectively when compared with the tyrphostin AG-17 (Item No. 10010248).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hori, H.,Nagasawa, H.,Ishibashi, M., et al. TX-1123: An antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioor. Med. Chem. Lett. 10(10), 3257-3265 (2002).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 228.2 |
| 分子式 | C14H12O3 |
| CAS号 | 503473-32-3 |
| 稳定性 | ≥ 2 years |
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