Etodolac
货号：
20833-1g 基本售价：
350.0 元 规格：
1 g
产品信息
概述| 货号 | 20833-1g |
| 描述 | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits both COX isoforms in vitro, with modest selectivity for COX-2 (IC50s = 12 µM for COX-1 and 2.2 µM for COX-2 in a human whole blood assay).1 Experimental evidence suggests that etodolac may have favorable tissue pharmacokinetics resulting in further COX-2 selectivity, indicated by favorable reduction in anti-inflammatory action with diminished gastric side effects.2,3 |
| 别名 | AY 24236;(±)-Etodolac;NIH 9918;NSC 282126; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Warner, T.D.,Giuliano, F.,Vojnovic, I., et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proceedings of the National Academy of Sciences of the United States of America 96(13), 7563-7568 (1999).
2.Dvornik, D.M. Tissue selective inhibition of prostaglandin biosynthesis by etodolac. Journal of Rheumatology 24, 40-50 (1997).
3.Riendeau, D.,Percival, M.D.,Brideau, C., et al. Etoricoxib (MK-0663): Preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. Journal of Pharmacology and Experimental Therapeutics 296, 558-566 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 287.4 |
| 分子式 | C17H21NO3 |
| CAS号 | 41340-25-4 |
| 稳定性 | ≥ 2 years |
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