| 货号 | 20813-1mg |
| 描述 | Lofepramine is a first generation tricyclic antidepressant that is extensively metabolized to desipramine.1 It potently inhibits serotonin and norepinephrine transporters (Kds = 70 and 5.4 nM, respectively) and less potently antagonizes serotonin, histamine, and muscarinic receptors.2,3,4 |
| 别名 | Lopramine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lancaster, S.G. and Gonzalez, J.P. Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 37(2), 123-140 (1989). 2.Tatsumi, M.,Groshan, K.,Blakely, R.D., et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. European Journal of Pharmacology 340(2-3), 249-258 (1997). 3.Cusack, B.,Nelson, A. and Richelson, E. Binding of antidepressants to human brain receptors: Focus on newer generation compounds. Psychopharmacology (Berl) 114(4), 559-565 (1994). 4.Stanton, T.,Bolden-Watson, C.,Cusack, B., et al. Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics. Biochemical Pharmacology 45(11), 2352-2354 (1993). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 419 |
| 分子式 | C26H27ClN2O |
| CAS号 | 23047-25-8 |
| 稳定性 | ≥ 2 years |
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