| 货号 | 20810-1mg |
| 描述 | M50054 is a cell-permeable inhibitor of the activation of caspase-3, blocking characteristic features of apoptosis, including DNA fragmentation and externalization of phosphatidylserine.1 It blocks apoptosis in a variety of cell lines induced by different stimuli, including Fas ligand and etoposide (Item No. 12092).1 M50054 has been used to inhibit apoptosis in skin, Xenopus larvae, teleost fish, and planaria, particularly in the context of tissue regeneration.2,3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tsuda, T.,Ohmori, Y.,Muramatsu, H., et al. Inhibitory effect of M50054, a novel inhibitor of apoptosis, on anti-FAS-antibody-induced hepatitis and chemotherapy-induced alopecia. Eur. J. Pharmacol. 433(1), 37-45 (2001). 2.Beane, W.S.,Morokuma, J.,Lemire, J.M., et al. Bioelectric signaling regulates head and organ size during planarian regeneration. Develop. 140, 313-322 (2013). 3.Durant, F.,Lobo, D.,Hammelman, J., et al. Physiological controls of large-scale patterning in planarian regeneration: A molecular and computational perspective on growth and form. Regeneration 3(2), 78-102 (2016). 4.Tseng, A.-S.,Adams, D.S.,Qiu, D., et al. Apoptosis is required during early stages of tail regeneration in Xenopus laevis. Dev. Biol. 301(1), 62-69 (2007). 5.Sirbulescu, R.F. and Zupanc, G.K. Inhibition of caspase-3-mediated apoptosis improves spinal cord repair in a regeneration-competent vertebrate system. Neuroscience 171(2), 599-612 (2010). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 236.3 |
| 分子式 | C13H16O4 |
| CAS号 | 54135-60-3 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |