| 货号 | 20771-500mg |
| 描述 | Picrotoxin is a natural plant-derived poison that acts as a selective GABAA receptor antagonist.1,2 It is functional in vivo and is used to study the role of GABAA receptors in the central nervous system as well in the periphery.3,4 Picrotoxin induces seizures in adult and immature animals and is used to study GABAA-dependent seizures and drugs that block this pathway.5 |
| 别名 | Cocculin;NSC 403139; |
| 是否危险品 | 是 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bowery, N.G.,Bettler, B.,Froestl, W., et al. International union of pharmacology. XXXIII. Mammalian g-aminobutyric acidB receptors: Structure and function. Pharmacological Reviews 54(2), 247-264 (2002). 2.Newland, C.F. and Cull-Candy, S.G. On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat. J. Physiol. 447, 191-213 (1992). 3.Jiang, X.,Fuller, T.W.,Bandari, J., et al. Contribution of GABAA, glycine, and opioid receptors to sacral neuromodulation of bladder overactivity in cats. J. Pharmacol. Exp. Ther. 359(3), 436-441 (2016). 4.Kistsen, V.,Evstigneev, V.,Dubovik, B., et al. The effects of repetitive transcranial magnetic stimulation on picrotoxin-induced convulsions in mice. Adv. Clin. Exp. Med. 25(2), 317-325 (2016). 5.Velisek, L.,Veliskova, J. and Moshe, S.L. Developmental seizure models. Ital. J. Neurol. Sci. 16(1-2), 127-133 (1995). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% (mixture of Picrotin and Picrotoxinin) |
| 计算分子量 | 602.6 |
| 分子式 | C15H18O7 • C15H16O6 |
| CAS号 | 124-87-8 |
| 稳定性 | ≥ 2 years |
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