AZD 1981
货号：
20763-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20763-1mg |
| 描述 | AZD 1981 is a prostaglandin D2(PGD2; Item No. 12010) receptor antagonist with a pIC50 value of 8.4 for CRTH2/DP2 and >1,000-fold selectivity over DP1.1 It has been shown to block functional responses in eosinophils, Th2 cells, and basophils and is currently under clinical evaluation as a potential therapeutic agent in respiratory diseases including asthma.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schmidt, J.A.,Bell, F.M.,Akam, E., et al. Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma. Br. J. Pharmacol. 168(7), 1626-1638 (2013).
2.Sykes, D.A.,Bradley, M.E.,Riddy, D.M., et al. Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy. Mol.Pharmacol. 89(5), 593-605 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 388.9 |
| 分子式 | C19H17ClN2O3S |
| CAS号 | 802904-66-1 |
| 稳定性 | ≥ 2 years |
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