Tramiprosate
货号：
20701-1g 基本售价：
350.0 元 规格：
1 g
产品信息
概述| 货号 | 20701-1g |
| 描述 | Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation.1 Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates.2 It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABABreceptors.3 |
| 别名 | Homotaurine;NC 531;NC 758;NSC 77071;3-Sulfopropylamine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gervais, F.,Chalifour, R.,Garceau, D., et al. Glycosaminoglycan mimetics: A therapeutic approach to cerebral amyloid angiopathy. Amyloid 8(Suppl. 1), 28-35 (2001).
2.Santa-Maria, I.,Hernandez, F.,Del Rio, J., et al. Tramiprostate, a drug of potential interest for the treatment of Alzheimer’s disease, promotes an abnormal aggregation of tau. Molecular Neurodegeneration 2, 17-29 (2007).
3.Giotti, A.,Luzzi, S.S. and Zilletti, L. Homotaurine: A GABAB antagonist in guinea-pig ileum. Br. J. Pharmac. 79, 855-862 (1983).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥95% |
| 计算分子量 | 139.2 |
| 分子式 | C3H9NO3S |
| CAS号 | 3687-18-1 |
| 稳定性 | ≥ 2 years |
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