| 货号 | 20678-1g |
| 描述 | Lumefantrine is an antimalarial drug that is used in combination with artemether (Item No. 11815).1 The pairing of lumefantrine and artemether is a major form of oral artemisinin combination therapy used against uncomplicated P. falciparummalaria.2,3 Lumefantrine also blocks the rapidly activating delayed-rectifier potassium channel (IKr; IC50 = 8.1 µM).4 |
| 别名 | Benflumetol;CPG-56695; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pascual, A.,Parola, P.,Benoit-Vical, F., et al. Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum. Malar.J. 11, 1-9 (2012). 2.Askling, H.H.,Bruneel, F.,Burchard, G., et al. Management of imported malaria in Europe. Malar.J. 11, 1-15 (2012). 3.Mayxay, M.,Khanthavong, M.,Chanthongthip, O., et al. Efficacy of artemether-lumefantrine, the nationally-recommended artemisinin combination for the treatment of uncomplicated falciparum malaria, in southern Laos. Malar.J. 11(1), 1-17 (2012). 4.Du, L.P.,Tsai, K.C.,Li, M.Y., et al. The pharmacophore hypotheses of IKr potassium channel blockers: Novel class III antiarrhythmic agents. Bioorg. Med. Chem. Lett. 14(18), 4771-4777 (2004). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 528.9 |
| 分子式 | C30H32Cl3NO |
| CAS号 | 82186-77-4 |
| 稳定性 | ≥ 2 years |
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