PTP Inhibitor II
货号：
20629-5g 基本售价：
350.0 元 规格：
5 g
产品信息
概述| 货号 | 20629-5g |
| 描述 | PTP inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)).1 PTP inhibitor II binds with lower affinity than PTP Inhibitor I (Item No. 19766) with Ki values of 128 and 43 μM, respectively.1 SHP-1 has known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.2 |
| 别名 | α-Bromo-4’-methoxyacetophenone;ω-Bromo-4’-methoxyacetophenone;4-(Bromoacetyl)anisole;4-Methoxyphenacyl bromide;NSC 129010;Protein Tyrosine Phosphatase Inhibitor II; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Arabaci, G.,Guo, X.C.,Beebe, K.D., et al. αHaloacetophenone derivatives as photoreversible covalent inhibitors of protein tyrosine phosphatases. Journal of the American Chemical Society 121(21), 5085-5086 (1999).
2.Heneberg, P. Use of protein tyrosine phosphatase inhibitors as promising targeted therapeutic drugs. Current Medicinal Chemistry 16(6), 706-733 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 229.1 |
| 分子式 | C9H9BrO2 |
| CAS号 | 2632-13-5 |
| 稳定性 | ≥ 2 years |
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