AM4113
货号：
20581-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20581-1mg |
| 描述 | AM4113 is a cannabinoid receptor 1 (CB1)-selective neutral antagonist that binds to CB1 and CB2 with Ki values of 0.89 and 92 nM, respectively.1 In rats, it has been shown to reduce food intake and food-reinforced behavior, such as time spent feeding, thereby reducing weight gain without inducing nausea.2 This compound has also been used to study the abuse-related effects of nicotine, as well as the effects of nicotine on anxiety and depressive-like behavior in rats.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sink, K.S.,McLaughlin, P.J.,Wood, J.A.T., et al. The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats. Neurospsychopharmacology 33(4), 946-955 (2008).
2.Salamone, J.D.,McLaughlin, P.J.,Sink, K., et al. Cannabinoid CB1 receptor inverse agonists and neutral antagonists: Effects on food intake, food-reinforced behavior and food aversions. Physiol. Behav. 91(4), 383-388 (2007).
3.Gueye, A.B.,Pryslawsky, Y.,Trigo, J.M., et al. The CB1 neutral antagonist AM4113 retains the therapeutic efficacy of the inverse agonist rimonabant for nicotine dependence and weight loss with better psychiatric tolerability. Int. J. Neuropsychopharmacol. (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 380.7 |
| 分子式 | C17H12Cl3N3O |
| CAS号 | 614726-85-1 |
| 稳定性 | ≥ 2 years |
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