AN3365 (hydrochloride)
货号：
20572-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20572-1mg |
| 描述 | AN3365 (hydrochloride) is a potent and selective bacterial leucyl-tRNA synthetase inhibitor active against Gram-negative bacteria.1 It is a member of a novel class of boron-containing compounds, the aminomethyl benzoxoaboroles, that have potential to combat multidrug resistance.2 It is active against many microbial strains, including strains of Enterobacteriaceae(MIC50/90 = 0.5/1 µg/ml) and the non-fermentative Gram-negative clinical isolates P. aeruginosa,A. baumannii,S. maltophilia, and B. cepacid(MIC50/90s = 4/8, 4/8, 2/4, and 8/32 µg/ml, respectively).1 However, in a Phase II clinical trial for complicated urinary tract infections, bacterial resistance occurred very rapidly and the study was terminated.3 |
| 别名 | Epetraborole;GSK2251052; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mendes, R.E.,Alley, M.R.,Sader, H.S., et al. Potency and spectrum of activity of AN3365, a novel boron-containing protein synthesis inhibitor, tested against clinical isolates of Enterobacteriaceae and nonfermentative gram-negative bacilli. Antimicrob. Agents and Chemother. 57(6), 2849-2857 (2013).
2.Hernandez, V.,Crépin, T.,Palencia, A., et al. Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria. Antimicrob. Agents and Chemother. 57(3), 1394-1403 (2013).
3.ODwyer, K.,Spivak, A.T.,Ingraham, K., et al. Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob. Agents and Chemother. 59(1), 289-298 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 273.5 |
| 分子式 | C11H16BNO4 • HCl |
| CAS号 | 1234563-16-6 |
| 稳定性 | ≥ 2 years |
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