BRD7116
货号：
20570-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20570-1mg |
| 描述 | BRD7116 is a bis-aryl sufone that acts as a selective inhibitor of leukemia stem cell activity. It exhibits an EC50 value of 200 nM for leukemia stem cells isolated from the bone marrow of leukemic animals in co-culture but does not affect normal hematopoietic stem cells or AML cell lines (EC50s = 20 µM).1 Its exact mechanism is not well understood but is thought to involve impairment of the stroma’s ability to support leukemia stem cells by inducing transcriptional changes consistent with myeloid differentiation.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hartwell, K.A.,Miller, P.G.,Mukherjee, S., et al. Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nat. Chem. Biol. 9(12), 840-848 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 496.7 |
| 分子式 | C28H36N2O4S |
| CAS号 | 329059-55-4 |
| 稳定性 | ≥ 2 years |
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