| 货号 | 20539-1g |
| 描述 | 5-hydroxy-L-Tryptophan (5-HTP) is an intermediate in the biosynthesis of serotonin from tryptophan.1 When injected systemically in animals, 5-HTP is converted to serotonin and has both peripheral and central nervous system effects.2,3,4Inex vivo studies, 5-HTP can be metabolized to melatonin with circadian rhythmicity, using serotonin as an intermediate.5 5-HTP can also be synthesized by gut microbiota and acts as an activator of the aryl hydrocarbon receptor.6 |
| 别名 | 5-HTP;Oxitriptan; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Martinez, A.,Knappskog, P.M. and Haavik, J. A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosyntheis. Current Medicinal Chemistry 8, 1077-1091 (2001). 2.Haberzettl, R.,Fink, H. and Bert, B. The murine serotonin syndrome - evaluation of responses to 5-HT-enhancing drugs in NMRI mice. Behav. Brain Res. 277, 204-210 (2015). 3.Laporta, J.,Moore, S.A.E.,Weaver, S.R., et al. Increasing serotonin concentrations alter calcium and energy metabolism in dairy cows. J. Endocrinol. 226(1), 43-55 (2015). 4.Schmid, C.L. and Bohn, L.M. Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a β-arrestin2/Src/Akt signaling complex in vivo. Journal of Neuroscience 30(40), 13513-13524 (2010). 5.Cahill, G.M. and Besharse, J.C. Circadian regulation of melatonin in the retina of Xenopus laevis: imitation by serotonin availability. J. Neurochem. 54(2), 716-719 (1990). 6.Sridharan, G.V.,Choi, K.,Klemashevich, C., et al. Prediction and quantification of bioactive microbiota metabolites in the mouse gut. Nat. Commun. 5, 5492 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 220.2 |
| 分子式 | C11H12N2O3 |
| CAS号 | 895096 |
| 稳定性 | ≥ 2 years |
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