(+)-Biotin 4-Amidobenzoic Acid (sodium salt)
货号：
20534-5mg 基本售价：
350.0 元 规格：
5 mg
产品信息
概述| 货号 | 20534-5mg |
| 描述 | (+)-Biotin 4-amidobenzoic acid is a substrate of biotinidase, which cleaves biotin amide to give biotin in vivo. Biotin is an essential coenzyme for certain carboxylases and is used to modify histones and regulate gene transcription.1 Biotinidase has key roles in intestinal absorption of biotin, the transport of biotin in plasma, and in the regulation of histone biotinylation.1 (+)-Biotin 4-amidobenzoic acid is hydrolyzed by biotinidase to release 4-aminobenzoic acid (PABA), which can be quantified by either fluorescent or colorimetric methods.2 This approach is used in biotinidase activity assays in newborn screening protocols to evaluate biotinidase deficiency.3 |
| 别名 | (+)-Biotin PABA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zempleni, J.,Hassan, Y.I. and Wigeratne, S.S.K. Biotin and biotinidase deficiency. Expert. Rev. Endocrinol. Metab. 3(6), 715-724 (2008).
2.Kobza, K.A.,Chaiseeda, K.,Sarath, G., et al. Biotinyl-methyl 4-(amidomethyl)benzoate is a competitive inhibitor of human biotinidase. J. Nutr. Biochem. 19(12), 826-832 (2008).
3.Szabó, E.,Szatmári, I.,Szönyi, L., et al. Quantitative analytical method for the determination of biotinidase activity in dried blood spot samples. Anal. Chem. 87(20), 10573-10578 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 385.4 |
| 分子式 | C17H20N3O4S • Na |
| CAS号 | 102418-74-6 |
| 稳定性 | ≥ 2 years |
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