Methoxy-X04
货号：
20476-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20476-1mg |
| 描述 | Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid.1 It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimers disease.1,2Forin vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging.2 Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Klunk, W.E.,Backsai, B.J.,Mathis, C.A., et al. Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.. J. Neuropathol. Exp. Neurol. 61(9), 797-805 (2002).
2.Burgold, S.,Bittner, T.,Dorostkar, M.M., et al. In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks. Acta. Neuropathol. 121(3), 327-335 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 344.4 |
| 分子式 | C23H20O3 |
| CAS号 | 863918-78-9 |
| 稳定性 | ≥ 2 years |
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