CX-5011 (sodium salt)
货号：
20474-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 20474-500ug |
| 描述 | CX-5011 is a highly selective and potent inhibitor of protein kinase CK2 (IC50 = 0.175 nM for native CK2), a pro-survival and anti-apoptotic kinase highly expressed in cancer cells.1,2 It was highly selective for CK2 over a panel of 235 protein kinases.1 It induces apoptosis, has anticancer properties in vitro, and appears to overcome the drug resistance phenotype that is partially induced by CK2.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Battistutta, R.,Cozza, G.,Pierre, F., et al. Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer. Biochemistry 50(39), 8478-8488 (2011).
2.Zanin, S.,Borgo, C.,Girardi, C., et al. Effects of the CK2 inhibitors CX-4945 and CX-5011 on drug-resistant cells. PLoS One 7(11), e49193 (2012).
3.Salizzato, V.,Borgo, C.,Cesaro, L., et al. Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies. Oncotarget 7(14), 18204-18218 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 362.3 |
| 分子式 | C20H11N4O2 • Na |
| CAS号 | 1333382-30-1 |
| 稳定性 | ≥ 2 years |
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