ML-162
货号：
20455-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 20455-500ug |
| 描述 | ML-162 is a small molecule that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50 = 25 nM in HRASV12-expressing BJ fibroblasts with 23-fold reduced potency for wild-type).1 It shares a similar structure but is more potent and selective than (1S,3R)-RSL3 (Item No. 19288), a previously reported inhibitor of RAS oncogene-expressing cells (IC50 = 100 nM in HRASV12-expressing BJ fibroblasts with 8-fold reduced potency for wild-type).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Weïwer, M.,Bittker, J.A.,Lewis, T.A., et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg. Med. Chem. Lett. 22(4), 1822-1826 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 477.4 |
| 分子式 | C23H22CI2N2O3S |
| CAS号 | 1035072-16-2 |
| 稳定性 | ≥ 2 years |
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