| 货号 | 20447-1mg |
| 描述 | ZM 241385 is a potent antagonist of α2a adenosine receptors (pIC50 = 9.52 for displacement of 5’-N-ethylcarboxamidoadenosine from rat phaeochromocytoma cell membranes).1,2 It displays little or no activity at other α adenosine receptors. ZM 241385 is active in vivo.3,4 It acts as an inverse agonist at constitutively active mutants of the human α2a adenosine receptor.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Poucher, S.M.,Keddie, J.R.,Singh, P., et al. The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonist. Br. J. Pharmacol. 115(6), 1096-1102 (1995). 2.Linden, J.,Thai, T.,Figler, H., et al. Characterization of human A2B adenosine receptors: Radioligand binding, western blotting, and coupling to Gq in human embryonic kidney 293 cells and HMC-1 mast cells. Molecular Pharmacology 56(4), 705-713 (1999). 3.Keddie, J.R.,Poucher, S.M.,Shaw, G.R., et al. In vivo characterisation of ZM 241385, a selective adenosine A2A receptor antagonist. Eur. J. Pharmacol. 301(1-3), 107-113 (1996). 4.Poucher, S.M.,Keddie, J.R.,Brooks, R., et al. Pharmacodynamics of ZM 241385, a potent A2a adenosine receptor antagonist, after enteric administration in rat, cat and dog. J. Pharm. Pharmacol. 48(6), 601-606 (1996). 5.Li, Q.,Ye, K.,Blad, C.C., et al. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. J. Pharmacol. Exp. Ther. 320(2), 637-645 (2007). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 337.3 |
| 分子式 | C16H15N7O2 |
| CAS号 | 139180-30-6 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |