TCS 401
货号：
20393-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20393-1mg |
| 描述 | TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 µM).1 It inhibits the protein phosphatases CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1, and LAR D1D2 at much higher concentrations (Kis = 59, 560, 1,100, >2,000, >2,000, and >2,000 μM, respectively).1 Several PTPs have been proposed to act as negative regulators of insulin signaling, thus this enzyme is a potential drug target in diabetes. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Iversen, L.F.,Andersen, H.S.,Branner, S., et al. Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J. Biol. Chem. 275(14), 10300-10307 (2000).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 306.7 |
| 分子式 | C10H10N2O5S • HCl |
| CAS号 | 243966-09-8 |
| 稳定性 | ≥ 2 years |
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