| 货号 | 20388-5mg |
| 描述 | Flecainide is an inhibitor of cardiac late sodium current (late INa; IC50 = 3.4 µM) and delayed-rectifier potassium current (IKr; IC50 = 1.5 µM).1,2,3 It has been used clinically to suppress arrhythmias and sodium-dependent calcium overload associated with myocardial ischemia and heart failure.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ramos, E., and OLeary, M.E. State-dependent trapping of flecainide in the cardiac sodium channel. J.Physiol. 560(pt. 1), 37-49 (2004). 2.Belardinelli, L.,Liu, G.,Smith-Maxwell, C., et al. A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias. Journal of Pharmacology and Experimental Therapeutics 344(1), 23-32 (2013). 3.Gutman, G.A.,Chandy, K.G.,Grissmer, S., et al. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacological Reviews 57(4), 473-508 (2005). 4.Khairy, P., and Nattel, S. New insights into the mechanisms and management of atrial fibrillation. Can.Med.Assoc.J. 167(9), 1012-1020 (2002). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 474.4 |
| 分子式 | C17H20F6N2O3 • C2H4O2 |
| CAS号 | 54143-56-5 |
| 稳定性 | ≥ 2 years |
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