RPI-1
货号：
20384-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20384-1mg |
| 描述 | RPI-1 is an ATP-dependent RET kinase inhibitor. It has been shown to selectively inhibit the anchorage-independent growth of NIH3T3 cells transformed by the ret/ptc1 oncogene with an IC50 value of 0.97 µM.1 In a spontaneously metastasizing lung carcinoma xenograft mouse model, daily oral treatment with RPI-1 was reported to significantly reduce spontaneous lung metastases.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lanzi, C.,Cassinelli, G.,Pensa, T., et al. Inhibition of transforming activity of the ret/ptc1 oncoprotein by a 2-indolinone derivative. Int.J.Cancer 85(3), 384-390 (2000).
2.Cassinelli, G., and Lanzi, C. Inhibition of c-Met and prevention of spontaneous metastatic spreading by the 2-indolinone RPI-1. Mol.Cancer Ther. 5(9), 2388-2397.
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 279.3 |
| 分子式 | C17H15NO4 |
| CAS号 | 269730-03-2 |
| 稳定性 | ≥ 2 years |
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